Maheshwari GK, Baboo HA, Gopal U, Wadhwa MK. Risks of medication-related osteonecrosis of the jaw, The multiple etiologies of angular cheilitis, Why you should perform oral cancer screenings on every dental patient, An excellent resource for Oral Cancer Awareness Month, Lichen planus pemphigoides: An autoimmune blistering disease, Cannabis: What dental providers need to know, Nancy W. Burkhart, EdD, MEd, BSDH, AAFAAOM. Mohd Ridah LJ, A Talib N, Muhammad N, Hussain FA, Zainuddin N. p16 Tumor Suppressor Gene Methylation in Diffuse Large B Cell Lymphoma: A Study of 88 Cases at Two Hospitals in the East Coast of Malaysia. Four treatment response classes were defined, as follows: complete response (CR, 100% resolution); partial response (PR, 50100% resolution); no response (<50% resolution); and progression of disease (PD, tumour enlarged after treatment). The phenomenon was observed in our PTCL case and is also mentioned in Steve As research [13]. Positive and negative controls were included in each batch of staining. Ekstrom-Smedby K. Epidemiology and etiology of non-Hodgkin lymphoma--a review. Federal government websites often end in .gov or .mil. Gastroesophageal reflux in bronchial asthma patients. 2008;88:2068. One patient in the literature died 18months after diagnosis despite being in an early stage. 2023 BioMed Central Ltd unless otherwise stated. 2017 Feb;274(2):931-937. doi: 10.1007/s00405-016-4307-8. Domanski HA, Akerman M. Fine-needle aspiration cytology of tongue swellings: a study of 75 cases. This patient had a partial response to chemotherapy and died 63months after diagnosis. From 2010 to 2017, a total of 2088 cases of lymphoma were diagnosed and treated at PUMCH. Fakhry C, Westra WH, Li S, Cmelak A, Ridge JA, Pinto H, Forastiere A, Gillison ML. Antibodies against CD3, CD20, CD4, CD5, CD10, CD21, and CD56 were from Novocastra, Leica Biosystems Newcastle, Ltd. Antibodies of CD79, Bcl-6, Mum-1, c-Myc, Ki-67, and AE1/AE3, ALK were from Invitrogen, USA. https://doi.org/10.1007/978-3-319-22822-8_13. Lee ES, Kim LH, Abdullah WA, Peh SC. The site is secure. showed that 74% of DLBCL cases have P16 methylation and a relatively old age [32]. Two probes (EBV and HPV) were used for all seven cases. The most common subtype of NHLs of the tongue base is DLBCL, and the occurrence at this site may have a good prognosis. Yuen A, Jacobs C. Lymphomas of the head and neck. ENT manifestations of gastroesophageal reflux. Of the 6 B-cell NHL cases, 5 were DLBCLs and 1 was MCL. Expression and alteration of p16 in diffuse large B cell lymphoma. FISH detection found that one case had a single Bcl-2 rearrangement and one case had a single Bcl-6 rearrangement. The clinical features of tongue base involvement by NHL are not specific [17]. These lymphoid tissues are controlled by specialized cells that arm themselves to attack and destroy foreign invaderssuch as bacteria, fungi, or virusesthrough phagocytosis or the production of antibodies. This is because reactive growth of lymphoid tissue can be difficult to distinguish from the most serious neoplastic lesions.1. This may be because the case occurred before drugs such as rituximab were widely available. Curr Top Microbiol Immunol. Leuk Res. 2004;103:27582. External beam radiation has been successful in a single case [6]. J Postgrad Med. Accessibility Radiology. Pseudotumours of the oropharynx due to muscular contraction. official website and that any information you provide is encrypted 2000;46:2112. Primary extra-nodal non-Hodgkin's lymphoma of the cheek. J Oral Maxillofac Pathol. To learn more, please visit our, Internal Medicine - Hematology & Oncology, It means that there is an increase of the number of a type of white, called lymphocytes. Mod Pathol. However, HPV infections have been identified with increasing frequency in patients with oropharyngeal squamous cell carcinoma, which is a predisposing risk factor [29]. The most common histologic subtype was diffuse large B-cell lymphoma (DLBCL), which occurred in five cases. Lee JT, Paquette R, Sercarz JA, Wang MB. Morphologically, LH is identified by dense lymphoid hyperplasia within the lamina propria and submucosa, replacing mucous glands. 1970 Dec;8(3):413-24. Nancy W. Burkhart, EdD, BSDH, AFAAOM, is an adjunct associate professor in the Department of Periodontics-Stomatology, College of Dentistry, Texas A&M University, Dallas, Texas. Positive staining was indicated by brown punctate dots in the cytoplasm. Accessibility To our knowledge, none of these have highlighted the presence of airway obstruction related to pharyngeal lymphoid hyperplasia. Dr. Burkhart was awarded an affiliate fellow status in the American Academy of Oral Medicine in 2016. The prognosis for MCL seems to be poorer than that for DLBCL at the base of the tongue. Google Scholar. Patricia Uherova et al. By that time, and at one week after discharge, the pharynx appeared within normal limits. Acta Oncol. It is caused by an abnormal expansion of the interfollicular zones but is confined within the lymph node capsule. She is founder and cohost of the International Oral Lichen Planus Support Group (dentistry.tamhsc.edu/olp) and coauthor of General and Oral Pathology for the Dental Hygienist, now in its third edition. Regezi JA, Sciubba JJ, Jordan RCK. Depending upon the location of the RLH, the appearance of tissue may vary. 2017;18:27815. Some tumour cells were large cells similar to diffuse large B cells in H&E slides (200x). Clinically this lesion presented as a painless ulcer, which mimicked carcinoma of the tongue. While an association with bacterial infection has not been clearly identified, one aggressive case of FLH has been linked to the presence of Epstein-Barr virus, causing clonal arrangement (expansion) in the local tissue DNA [4]. Cancer. There is usually a bilateral . https://doi.org/10.4103/0973-1482.136024. e. Tumour cells were positive for Cyclin D1 (200x). Am J Hematol. Article Lymphoid hyperplasia of the tongue is a very rare benign lymphoproliferative lesion that closely resembles carcinoma or lymphoma, clinically or histopathologically. Despite some degree of resolution, lingual and palatine tonsillectomy was performed using electrocautery 7 days after tracheotomy. It is caused by an abnormal proliferation of secondary follicles and occurs principally in the cortex without broaching the lymph node capsule. 2017;58:203342. Int J Oral Maxillofac Surg. Google Scholar. Non-translocation was determined based on the co-localization of red and green signals, while separation of the red and green signals reflected translocation. Pathol Res Pract. a. MRI showed a mass in the base of the tongue sticking to the pharyngeal cavity and making it obviously narrow. 2015;466:93100. One case presented as multiple deep ulcers. Never disregard or delay professional medical advice in person because of anything on HealthTap. All 7 lymphomas were localized at the base of the tongue. Roentgen examination of the oropharynx and oral cavity. 7982, 2009. An official website of the United States government. Primary intestinal T-cell and NK-cell lymphomas: a clinicopathological and molecular study from China focused on type II enteropathy-associated T-cell lymphoma and primary intestinal NK-cell lymphoma. Would you like email updates of new search results? This is the first study to report on both HPV and EBV infection status in tongue base lymphoma. However, the relationship between HPV and lymphomas of the head and neck remains largely unknown. Saxman S, Righi P. Mantle cell lymphoma appearing as a tongue base mass. Get answers from Oncologist and Hematologists and top U.S. doctors, Our doctors evaluate, diagnose, prescribe, order lab tests, and recommend follow-up care. Postoperatively the patient was deemed unsafe for extubation and transferred to the intensive care unit while placed on high-dose intravenous dexamethasone. Clinical images of entities may be beneficial for documentation purposes, as they may be viewed during future appointments should there be recurrences. https://doi.org/10.1016/j.ijom.2004.08.009. 2, pp. We thank Violette Ghali, Gina Elhammady, Mark Persky and Songyang Yuan for confirming the pathological diagnosis. and has since been primarily reported in the skin, breasts, gastrointestinal tract, lungs, and nasopharynx [2]. Human papillomavirus (HPV) and Epstein-Barr virus (EBV) are important aetiological risk factors for tumours of the head and neck. Spectrum of a benign entity Radiology. Although they were in different stages, their prognosis was similarly good. LH most commonly affects older patients, with a mean age of 61 and female-to-male ratio of nearly 3:1. I understand that this is benign, but what could be the cause? The pathological diagnosis was MCL. Results came back "lymphoid hyperplasia". Examination and imaging (CT and MRI) showed a mass (4.6cm2.8cm1.5cm) at the left base of the tongue, which was biopsied. Visco C, Arcaini L, Brusamolino E, Burcheri S, Ambrosetti A, Merli M, Bonoldi E, Chilosi M, Viglio A, Lazzarino M, Pizzolo G, Rodeghiero F. Distinctive natural history in hepatitis C virus positive diffuse large B-cell lymphoma: analysis of 156 patients from northern Italy. b. H&E showed moderate to large cells with distorted nuclear contours (200 x). https://doi.org/10.22034/APJCP.2017.18.10.2781. 1997;76:356. Three patients are alive with disease and 2 are alive without disease. In the literature, findings of RLH are well-documented. Primary diffuse large B-cell lymphoma of the ovary is of a germinal Centre B-cell-like phenotype. [citation needed], Cutaneous lymphoid lesions may be observed in follicular, granulomatous or lymphoreticular pathologic patterns. Here, in our cases, none of our patients had EBV infection, but one DLBCL patient was HPV DNA positive and P16 protein positive, but HPV RNA negative, which may indicated HPV infection. L. P. Menasce, J. H. Shanks, S. S. Banerjee, and M. Harris, Follicular lymphoid hyperplasia of the hard palate and oral mucosa: report of three cases and a review of the literature, Histopathology, vol. Focal aggregates of lymphoid tissue are smaller, but they perform the same function by responding to antigens that enter the body through the mouth. MCLs in the tongue base are even rarer. Only membranous marker expression was considered positive for CD3, CD20, CD4, CD5, CD8, CD10, CD21, CD23, CD43, and CD56. Ann Diagn Pathol. Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Delabie J, Ott G, Muller-Hermelink HK, Campo E, Braziel RM, Jaffe ES, Pan Z, Farinha P, Smith LM, et al. Increasingly, cancers at the base of the tongue are . 2010;77:96105. 1984 Apr;151(1):123-6. doi: 10.1148/radiology.151.1.6322222. In addition, HPV-positive tumours are a unique clinical entity distinct from HPV-negative tumours [30], and involve, for instance, less exposure to tobacco. Objective: This paper describes a case where a patient diagnosed with tongue base lymphoid hyperplasia was successfully treated with radiofrequency excision and interstitial radiofrequency-induced thermotherapy. Two patients died of the disease at three and 63months after diagnosis, respectively. This is consistent with head and neck research findings [6, 26]. CAS Disclaimer. Springer Nature. I am taking medicine nd it is reducing but its been 3 weeks now? Tongue base lymphoid hyperplasia, also known as pseudolymphoma, is an uncommon benign entity associated with a rapid increase in the abundance of lymphocytes contained within or outside of lymph nodes. Lymphoid (follicular) hyperplasia may occur on the borders of the tongue at the junction of the anterior part ('oral tongue') and the base of the tongue [4]. As always, continue to ask good questions and listen to what your patients are telling you! Acta Ophthalmol. Squamous cells also make up the top layer of skin and other body parts such as the lungs and esophagus. In our case, there were sheets of large cells with obvious nucleoli very similar to those in DLBCL. 3). Clipboard, Search History, and several other advanced features are temporarily unavailable. https://doi.org/10.1309/YHFE-R65B-D3LK-3GGV. Benign lymphoid hyperplasia (BLH) is a benign proliferation of lymphoid tissue in response to external irritation. The most common symptoms are varying degrees of discomfort in the pharynx, such as the sensation of a foreign body or choking while drinking. The lymphoid follicles at the base of the tongue can be detected when examining the pharynx of adults, but the presence of large follicles, denoted "severe" hypertrophy of the base of the tongue (HBT) is rare. This article is available as a PDF only. We not only report on the general clinicopathological features, including age, gender, tumour location, histological subtypes, grading and staging, but also provide important information related to prognosis and treatment. All patients were diagnosed by either biopsy or tumor resection. 2010;39:86972. Reported cases involve the conjunctiva, liver, gastrointestinal tract, stomach, lungs, paranasal sinuses, and many cutaneous areas. Except in one case, all patients exhibited a tongue base mass with smooth and intact membrane surface. 2, pp. https://doi.org/10.1093/jnci/djn011. volume15, Articlenumber:30 (2020) D. L. Harsany, J. Ross, and W. E. Fee, Follicular lymphoid hyperplasia of the hard palate simulating lymphoma, OtolaryngologyHead and Neck Surgery, vol. [1] The growth is termed hyperplasia which may result in enlargement of various tissue including an organ, or cause a cutaneous lesion. Had biopsy on axillary lymph node. Lymphoid hyperplasia at the base of the tongue. 2006;30:85967. For potential or actual medical emergencies, immediately call 911 or your local emergency service. Severe benign lymphoid hyperplasia (LH) is unusual in the head and neck region, but the diagnosis of LH is of clinical importance as it may be confused with malignant lymphoma, both on clinical examination and pathologically. 1999;26:33845. The therapeutic response is related to the pathological subtype and several factors, such as old age, high grade histology, bulky lymph nodes, higher IPI score, and advanced stage [22, 24, 25]. Lopez-Guillermo A, Colomo L, Jimenez M, Bosch F, Villamor N, Arenillas L, Muntanola A, Montoto S, Gine E, Colomer D, Bea S, Campo E, Montserrat E. Diffuse large B-cell lymphoma: clinical and biological characterization and outcome according to the nodal or extranodal primary origin. The American Academy of Oral Medicine in 2016 NHL cases, 5 were DLBCLs and was. ):123-6. doi: 10.1148/radiology.151.1.6322222 showed a mass in the base of the and. Hyperplasia within the lymph node capsule, Peh SC Wadhwa MK were included in each of... 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